Polymorphisms Number of samples Hardy – Weinberg equilibrium Allele na Frequency Genotype nb Frequency CYP2C9*2 284 p=0.11 C T 521 47 0.92 0.08 СС СT TT 241 39 4 0.85 0.14 0.01 CYP2C9*3   283 p=0.86 A C 521 45 0.92 0.08 AA AC CC 240 41 2 0.85 0.14 0.01 VKORC1 1173 575 p=0.73 C T 685 465 0.60 0.40 CC CT TT 202 281 92 0.35 0.49 0.16 VKORC1 1542 574 p=0.53 G C 677 471 0.59 0.41 GG GC CC 196 285 93 0.34 0.50 0.16 CYP4F2 284 p=0.73 G A 433 135 0.76 0.24 GG GA AA 164 105 15 0.58 0.37 0.05 GGCX 565 p=0.04 C G 1041 89 0.92 0.08 CC CG GG 476 89 0 0.84 0.16 0.00 CYP2D6*3   350 p=0.59 A del 596 104 0.85 0.15 AA A/del del/del 255 86 9 0.73 0.25 0.03 CYP2D6*4 352 p=0.84 G A 551 153 0.78 0.22 GG GA AA 215 121 16 0.61 0.34 0.05 CYP1A2*1F 341 p=0.25 A C 468 214 0.69 0.31 AA AC CC 156 156 29 0.46 0.46 0.09 a number of chromosomes; b number of alleles

Table 8: Allele frequency and genotype distribution in the Russian population.