Drug HLA –allele association Organ system Included in the label / SPC Centrally authorised Abacavir HLA-B*5701 Skin Yes Lapatinib HLA-DQA1*201 Liver Yes Ximalagatran HAL-DRB1*07-DAQ1*02 Liver Withdrawn Lumiracoxib HLA-DRB1*1501-DQB10602 Liver Not authorised National authorisations Carbamazepine HLA-B*1502 Skin & mucous membranes Yes HLA-A*3101 Skin Yes Co-Amoxyclav HLA-DRB1*1501-DQB1*0602 Liver Recent review Flucloxacillin HLA-B*5701 Liver Not yet.

Table 2: HLA allele associations with product safety.