Likely Phenotype Genotypes Examples of Diplotypes
Ultrarapid metabolizer: normal or increased activity (~5–30% of patients) An individual carrying two increased-activity alleles (*17), or one functional allele (*1) plus one increased-activity allele (*17) *1/*17, *17/*17
Extensive metabolizer: homozygous wild-type or normal activity (~35–50% of patients) An individual carrying two functional (*1) alleles *1/*1
Intermediate metabolizer:heterozygote or intermediate activity (~18–45% of patients) An individual carrying one functional allele (*1) plus one loss-of-function allele (*2–*8) *1/*2, *1/*3
Table 1: Assigning likely CYP2C19 phenotypes based on genotypes.