| Group Assignment |
Week 1 Visit 2 |
Week 2 Visit 3 |
Week 3 Visit 4 |
Week 4 Visit 5 |
| Sequence A N=5 |
S/L 1.1 mg |
S/L 2.2 mg |
IV 0.2 mg |
S/L 2.2 mg with 240 ml water |
| Sequence B N=5 |
IV 0.2 mg |
S/L 2.2 mg |
S/L 1.1 mg |
S/L 2.2 mg with high fat diet |
Notes: 0.2 mg flumazenil IV was given over 15 seconds; S/L 1.1 mg is equal to one
puff of CRLS035; S/L 2.2 mg is equal to two puffs of CRLS035 |
