Flumazenil Concentrations (ng/mL)   Sublingual, 1.1 mg Fasting, no water n = 10 Sublingual, 2.2 mg Fasting, no water n = 10 Intravenous, 0.2 mg n = 10 Sublingual, 2.2 mg 240 mL water n = 5 Sublingual, 2.2 mg High fat meal n = 5 Time (hr) Mean ± SD Mean ± SD Mean ± SD Mean ± SD Mean ± SD 0 0   0   0   0   0   0.167 4.55 ± 1.61 6.00 ± 3.05 45.9 ± 63.9 7.26 ± 3.15 5.26 ± 2.43 0.5 4.75 ± 1.11 5.57 ± 1.82 3.44 ± 3.41 6.66 ± 1.79 4.00 ± 1.49 1 3.16 ± 0.79 5.09 ± 1.59 1.51 ± 1.01 4.38 ± 1.09 3.20 ± 1.41 1.5 2.21 ± 0.96 3.32 ± 1.15 1.01 ± 1.15 2.91 ± 0.66 2.39 ± 1.11 2 1.37 ± 0.54 2.23 ± 0.68 0.58 ± 0.38 1.96 ± 0.26 1.91 ± 0.75 4 0.48 ± 0.21 0.65 ± 0.30 0.26 ± 0.14 0.41 ± 0.18 0.47 ± 0.13 6 0.02 ± 0.06 0.08 ± 0.14 0   0   0.02 ± 0.05 12 0   0   0.03 ± 0.09 0   0.04 ± 0.08 Standard deviations were not calculated when all values were 0 ng/mL.

Table 3: Mean Plasma Concentrations of Flumazenil.