Parameter Dose, Route State Mean SD %CV Geometric mean Median Minimum Max N Cmax (ng/mL) 1.1 mg sublingual fasted 5.15 1.46 28.4 4.95 5.12 2.89 7.24 10 2.2 mg sublingual fasted 6.98 2.51 36.0 6.61 6.28 4.42 12.2 10 0.2 mg IV fasted 45.9 63.8 139 19.9 21.0 3.53 200 10 2.2 mg sublingual 240 mL water 7.48 2.91 39.0 7.03 6.48 4.10 11.7 5 2.2 mg sublingual high-fat meal 5.28 2.41 45.6 4.80 5.36 2.44 8.16 5 Tmax (hr) 1.1 mg sublingual fasted 0.433 0.140 32.4 0.402 0.500 0.167 0.500 10 2.2 mg sublingual fasted 0.484 0.380 78.7 0.356 0.334 0.167 1.00 10 0.2 mg IV fasted 0.250 0.263 105 0.200 0.167 0.167 1.00 10 2.2 mg sublingual 240 mL water 0.433 0.149 34.4 0.402 0.500 0.167 0.500 5 2.2 mg sublingual high-fat meal 0.234 0.149 63.8 0.208 0.167 0.167 0.500 5 Clast (ng/mL) 1.1 mg sublingual fasted 0.417 0.196 47.1 0.368 0.455 0.150 0.660 10 2.2 mg sublingual fasted 0.389 0.235 60.5 0.319 0.420 0.100 0.800 10 0.2 mg IV fasted 0.295 0.096 32.6 0.281 0.270 0.160 0.460 10 2.2 mg sublingual 240 mL water 0.410 0.184 44.9 0.378 0.410 0.230 0.680 5 2.2 mg sublingual high-fat meal 0.302 0.156 51.8 0.264 0.350 0.110 0.500 5 Tlast (hr) 1.1 mg sublingual fasted 4.20 0.63 15.1 4.17 4.00 4.00 6.00 10 2.2 mg sublingual fasted 4.80 1.03 21.5 4.70 4.00 4.00 6.00 10 0.2 mg IV fasted 4.60 2.67 58.2 4.17 4.00 2.00 12.0 10 2.2 mg sublingual 240 mL water 4.00 0 0 4.00 4.00 4.00 4.00 5 2.2 mg sublingual high-fat meal 6.00 3.46 57.7 5.40 4.00 4.00 12.0 5 AUC0-t (ng•hr/mL) 1.1 mg sublingual fasted 7.84 2.28 29.1 7.56 7.32 4.61 12.5 7.84 2.2 mg sublingual fasted 11.4 3.2 27.8 11.0 10.8 6.41 15.8 11.4 0.2 mg IV fasted 15.2 17.0 112 9.53 9.43 1.84 57.6 15.2 2.2 mg sublingual 240 mL water 10.6 2.5 23.3 10.3 10.0 7.36 13.8 10.6 2.2 mg sublingual high-fat meal 8.59 3.60 41.9 8.04 6.47 5.54 13.8 8.59 AUCinf (ng•hr/mL) 1.1 mg sublingual fasted 8.60 2.20 25.6 8.35 8.32 4.99 12.7 8.60 2.2 mg sublingual fasted 12.0 3.2 27.0 11.6 11.3 6.65 16.0 12.0 0.2 mg IV fasted 12.9 10.2 78.9 9.54 9.91 2.17 30.3 12.9 2.2 mg sublingual 240 mL water 11.1 2.6 23.0 10.9 10.3 7.98 14.8 11.1 2.2 mg sublingual high-fat meal 9.10 3.31 36.4 8.67 7.04 6.57 14.0 9.10 t1/2 (hr) 1.1 mg sublingual fasted 1.15 0.34 29.6 1.11 1.15 0.687 1.92 10 2.2 mg sublingual fasted 1.05 0.25 23.8 1.03 1.03 0.781 1.46 10 0.2 mg IV fasted 1.18 0.46 39.2 1.11 1.03 0.802 2.03 6 2.2 mg sublingual 240 mL water 0.891 0.187 21.0 0.874 1.02 0.660 1.04 5 2.2 mg sublingual high-fat meal 1.12 0.19 17.0 1.10 1.07 0.967 1.43 5

Table 4: Summary of statistics for pharmacokinetic parameters.