Parameter
State
Mean
SD
%CV
Geometric Mean
Median
Minimum
Maximum
Cmax (ng/mL)
fasted
6.98
2.51
36.0
6.61
6.28
4.42
12.2
+ water
7.48
2.91
39.0
7.03
6.48
4.10
11.7
+ meal
5.28
2.41
45.6
4.80
5.36
2.44
8.16
Ratio for water/fasted
1.072
1.064
1.033
Ratio for meal/fasted
0.757
0.726
0.854
Tmax (hr)
fasted
0.484
0.380
78.7
0.356
0.334
0.167
1.00
+ water
0.433
0.149
34.4
0.402
0.500
0.167
0.500
+ meal
0.234
0.149
63.8
0.208
0.167
0.167
0.500
Ratio for water/fasted
0.896
1.129
1.499
Ratio for meal/fasted
0.483
0.585
0.501
AUC0-t (ng•hr/mL)
fasted
11.4
3.2
27.8
11.0
10.8
6.41
15.8
+ water
10.6
2.5
23.3
10.3
10.0
7.36
13.8
+ meal
8.59
3.60
41.9
8.04
6.47
5.54
13.8
Ratio for water/fasted
0.929
0.944
0.930
Ratio for meal/fasted
0.755
0.734
0.602
AUC
0-∞
fasted
12.0
3.2
27.0
11.6
11.3
6.65
16.0
Table 6:
Pharmacokinetics comparison of fasted with no water, water 10 minutes after administration, and administration 30 minutes after a high fat meal.
