| Transporter |
Herbal compound |
Substrate/ Inhibitor |
IC50
(μM) |
Ki
(μM) |
Km
(μM) |
Reference |
| OAT1 |
Baicalein |
Inhibitor |
11.8 ± 6.2 |
ND |
ND |
[33] |
| |
Wogonin |
Inhibitor |
5.4 ± 2.8 |
ND |
ND |
[33] |
| |
Rosmarinic acid |
Inhibitor |
ND |
0.35 ± 0.06 |
ND |
[36] |
| |
Aristololchic acids (AA-I) |
Inhibitor |
0.44 ± 0.08 |
0.08 ± 0.15 |
ND |
[42] |
| |
Aristolochic acids (AA-II) |
Inhibitor |
1.06 ± 0.09 |
ND |
ND |
[42] |
| |
Rhein |
Inhibitor |
0.0771 ± 0.0055 |
0.0715 ± 0.0052 |
ND |
[36] |
| |
Gallic acid |
Inhibitor |
1.24 ± 0.36 |
1.08 ± 0.26 |
ND |
[37] |
| |
3-monoglucuronyl-glycyrrhetinic acid |
Substrate |
ND |
ND |
50.9 |
[43] |
| OAT3 |
Ursolic acid |
Inhibitor |
18.9 ± 8.20 |
ND |
ND |
[19] |
| |
Baicalin |
Inhibitor |
13.0 ± 5.1 |
ND |
ND |
[33] |
| |
Baicalein |
Inhibitor |
2.4 ± 1.3 |
ND |
ND |
[33] |
| |
Wogonin |
Inhibitor |
1.3 ± 0.3 |
ND |
ND |
[33] |
| |
Rosmarinic acid |
Inhibitor |
ND |
0.55 ± 0.25 |
ND |
[36] |
| |
Lithospermic acid |
Inhibitor |
ND |
0.59 ± 0.26 |
ND |
[36] |
| |
Salvianolic acid A |
Inhibitor |
ND |
0.16 ± 0.03 |
ND |
[36] |
| |
Aristololchic acids (AA-I) |
Inhibitor |
0.65 ± 0.08 |
0.84 ± 0.10 |
ND |
[42] |
| |
Aristolochic acids (AA-II) |
Inhibitor |
1.28 ± 0.18 |
ND |
ND |
[42] |
| |
Rhein |
Inhibitor |
0.0084 ± 0.0025 |
0.0077 ± 0.0074 |
ND |
[36] |
| |
Gallic acid |
Inhibitor |
9.02 ± 3.24 |
8.44 ± 3.03 |
ND |
[37] |
| |
3-monoglucuronyl-glycyrrhetinic acid |
Substrate |
ND |
ND |
21.3 |
[43] |
| OAT4 |
Baicalin |
Inhibitor |
15.6 ± 5.50 |
ND |
ND |
[33] |
ND: Not determined.