| Transporter |
Herbal compound |
Substrate/ Inhibitor |
IC50
(μM) |
Ki
(μM) |
Km
(μM) |
Reference |
| OATP2B1 |
Ursolic acid |
Inhibitor |
11.0 ± 5.0 |
ND |
ND |
[19] |
| |
Baicalin |
Inhibitor |
5.6 ± 3.2 |
ND |
ND |
[33] |
| |
Baicalein |
Inhibitor |
ND |
ND |
ND |
[33] |
| |
Wogonin |
Inhibitor |
ND |
ND |
ND |
[33] |
| |
Icariin |
Inhibitor |
6.4 ± 1.9 |
ND |
ND |
[78] |
| |
Silybin A |
Inhibitor |
4.5 |
ND |
ND |
[80] |
| |
Silybin B |
Inhibitor |
0.8 |
ND |
ND |
[80] |
| |
Silychristin |
Inhibitor |
3.6 |
ND |
ND |
[80] |
| OATP1B3 |
Gallic acid |
Inhibitor |
1.6 ± 0.6 |
ND |
ND |
[19] |
| |
Baicalin |
Inhibitor |
13.7 ± 3.6 |
ND |
ND |
[33] |
| |
Baicalein |
Inhibitor |
7.7 ± 2.4 |
ND |
ND |
[33] |
| |
Wogonin |
Inhibitor |
7.7 ± 3.1 |
ND |
ND |
[33] |
| |
Icariin |
Inhibitor |
3.0 ± 1.3 |
ND |
ND |
[78] |
| |
Silybin A |
Inhibitor |
2.7 |
ND |
ND |
[80] |
| |
Silybin B |
Inhibitor |
5.0 |
ND |
ND |
[80] |
| |
Silychristin |
Inhibitor |
36.4 |
ND |
ND |
[80] |
| |
Epicatechin-gallate |
Substrate |
ND |
ND |
34.1 |
[81] |
| |
Epigallocate-chin gallate |
Substrate |
ND |
ND |
13.2 |
[81] |
| |
Dioscin |
Substrate |
ND |
ND |
2.08 ± 0.27 |
[84] |
| OATP1B1 |
Baicalin |
Inhibitor |
121.0 ± 9.3 |
ND |
ND |
[33] |
| |
Baicalein |
Inhibitor |
172.6 ± 6.3 |
ND |
ND |
[33] |
| |
Wogonin |
Inhibitor |
>200 |
ND |
ND |
[33] |
| |
Icariin |
Inhibitor |
21.9 ± 2.0 |
ND |
ND |
[23] |
| |
Silybin A |
Inhibitor |
9.7 |
ND |
ND |
[80] |
| |
Silybin B |
Inhibitor |
8.5 |
ND |
ND |
[80] |
| |
Silychristin |
Inhibitor |
9.0 |
ND |
ND |
[80] |
| |
Periplocin |
Inhibitor |
ND |
ND |
ND |
[85] |
| |
Epigallocatechingallate |
Inhibitor |
7.8 |
ND |
ND |
[81] |
| OATP1A2 |
Epicatechingallate |
Substrate |
10.2 |
ND |
10.4 |
[81] |
| |
Epigallocatechingallate |
Substrate |
54.8 |
ND |
18.8 |
[81] |
| |
Quercetin |
Substrate |
ND |
ND |
2.3 ± 1.5 |
[83] |
| OATP4C1 |
3-monoglucuronyl-glycyrrhetinic acid |
Substrate |
ND |
ND |
33.1 |
[43] |
ND: not determined |
