| Polymorphism |
Genotype |
Frequency |
N |
Warfarin weekly dose |
P valuea |
| |
|
(%) |
|
Median |
25th-75th |
|
| MMP9 rs17576 (Gln279Arg, A>G) |
AAb |
41.9 |
95 |
25.00 |
16.25-33.75 |
0.01 |
| AG |
48.0 |
109 |
26.25 |
17.50-35.00 |
| GG |
10.1 |
23 |
16.25 |
8.75-26.25 |
| G allele |
34.2 |
|
|
|
|
| TNFSF14rs2291668 (c.147C>T) |
CCb |
71.4 |
162 |
23.75 |
17.50-35.00 |
0.98 |
| CT |
25.5 |
58 |
26.25 |
13.75-34.06 |
| TT |
3.1 |
07 |
23.75 |
26.25-35.00 |
| T allele |
15.9 |
|
|
|
|
| TNFSF14 rs344560 (Lys214Glu, G>A) |
GGb |
86.4 |
196 |
24.38 |
17.50-35.00 |
0.75 |
| GA |
12.7 |
29 |
25.00 |
15.00-30.63 |
| AA |
0.9 |
02 |
29.38 |
Ø |
| A allele |
7.3 |
|
|
|
|
| LTA rs1041981 (Thr60Asn, C>A) |
CCb |
40.8 |
92 |
25.00 |
15.00-34.69 |
0.22 |
| CA |
48.2 |
110 |
23.75 |
16.25-32.81 |
| AA |
11.0 |
25 |
28.75 |
20.00-36.88 |
| A allele |
35.2 |
160 |
|
|
|
| LTA rs909253 (c.252T>C) |
TTb |
40.8 |
93 |
25.00 |
15.00-34.38 |
0.19 |
| CT |
48.7 |
110 |
23.75 |
26.25-32.81 |
| CC |
10.5 |
24 |
28.75 |
20.00-37.81 |
| C allele |
34.8 |
|
|
|
|
aKruskall-Wallis test and Bonferroni correction for multiple comparison test (GG was different from AA+AG genotypes (p<0.05). bAncestral allele (www.ncbi.nlm.nih.gov).
|
