Gene Polymorphism (rs) Base substitution Amino acids substitution Variant Functional consequences Reference ADRB1 rs1801252 A231G Ser49Gly 231G ↑  receptor down regulation [38] (10q24-26) rs1801253 G1251C Gly389Arg 1251C ↑ interaction with G protein [39]           ↑ response to antagonists [40] ADRB2 rs1042711 T-47C Arg19Cys -47C ↓ADRB2 expression [31] (5q31-32)         ↓ interaction with G protein [31]   rs1042713 A285G Arg16Gly 285G ↑  receptor down regulation [20]   rs1042714 C318G Gln27Glu 318G ↓  receptor down regulation [20]           ↓ receptor degradation [20]   rs1800888 C730T Thr164Ile 730T ↓ affinity towards ligands [28]           ↓ interaction with G protein [28] ADRB3(8p12) rs4994 T190C Trp64Arg 190C ↓response to gonists    ↓  lipolysis [34,36]          [34,36]

↑- increased, ↓ - decreased

Table 1: Obesity-associated functional polymorphisms in genes encoding adrenergic receptors beta(ADRB).