Generic name Indication ADRs Pharmacogenomic test Reference Nevirapine HIV-1 infection and AIDS SJS/TEN HLA-B*3505 [36] Efavirenz HIV-1 infection and AIDS Central nervous system side-effects CYP2B6 [44,45,71] Abacavir HIV-1 infection and AIDS Hypersensitivity HLA-B*5701 [90] Stavudine HIV-1 infection and AIDS Lipodystrophy HLA-B*4001 [39] Allopurinol, Hyperuricemia and chronic gout SJS/TEN HLA-B*5801 [78,91] Carbamazepine Epilepsy seizures, bipolar disorder, and mood stabilizing SJS/TEN HLA-B*1502 [79,92,93] ADRs, adverse drug reactions; SJS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis; HLA, human leukocyte antigen; CYP, cytochrome P450.

Table 1: Selected adverse drug reactions and their pharmacogenomic markers.