CLASIFICATION

DRUGS

GENES - rs

ADVERSE EVENTS

Nucleoside

Reverse

Transcriptase

Inhibitors

Zidovudine

ABCC4 (MRP4)
A1203A - rs11568695

Anemia, neutropenia
Fatigue, malaise, headache
Nausea, vomiting
Myalgia, myopathy

Stavudine

POLG (Mit DNA)
R964C and E1143G

Peripheral neuropathy
Pancreatitis
Dyslipidaemia
Diarrhea

Lamivudine

ABCC2 (MRP2)
C421A-Q141K - rs2231142
Q126X - rs725522713
V12M - rs2231137
MRP4
3’ UTR - rs3742106

Headache, dry mouth

Abacavir

HLA-B*5701 - rs3093726
HCP-5 - rs2395029

Hypersensitivity syndrome (HSR)
Rash, fever, myalgia, malaise, nausea, vomiting,diarrhea

Tenofovir

ABCC4 (MRP4)
K1116K - rs1751034

Asthenia
Acute renal insufficiency
Proximal Tubulopathy
Fanconi syndrome

Non Nucleoside

Reverse

Transcriptase

Inhibitors

Nevirapine

ABCB1
I1143I - rs1045642
CYP2B6
Q172H - rs3745274
I328T - rs28399499

Hypersensitivity syndrome (HSR)
Skin rash
Elevations in liver function tests, Hepatitis, liver failure

Efavirenz

CYP2B6
Q172H - rs3745274
I328T - rs28399499
ABCB1 (MDR1)
I1143I - rs1045642

Peripheral Neuropathy

Protease

Inhibitors

Atazanavir

UGT1A1
UGT1A1*28- (rs8175347)

Hyperbilirubinemia, jaundice
Elevations in liver function tests, PR interval prolongation

Indinavir

UGT1A1
UGT1A1*28 - rs8175347
CYP3A4/ CYP3A5
CYP3A4*1B /CYP3A5*1

Hyperbilirubinemia, jaundice
Nephrolithiasis, flank pain

Ritonavir

ABCA1, APOA5, APOC3, APOE, CETP

Dyslipidaemia

Entry Inhibitor

Maraviroc

CCR5
Δ32 - rs333

Diarrhea, nausea
Upper respiratory tract infections, cough. Joint, muscle pain