Ka=Absorption rate constant, Ke=Elimination rate constant, Rin=Input rate, R0=Rate of elimination, IC50=half maximal inhibitory concentration, PK=Pharmacokinetic, PD=Pharmacodynamic. Parameter values used for simulation of warfarin levels and INR response time course during model development are shown in the Table 3.

Figure 5: Schematic representation of the indirect pharmacokineticpharmacodynamic (PK-PD) model to be employed.