CYP2C9   VKORC1 Allelic Variant Change to Protein Activity Allelic Variant Change to Protein Activity *1(WT) Reference Normal WT# Reference Normal *2 (430C>T) Arg144Cys Decreased -1639 G>A Promoter Deficient *3 (1075A>C) Ile359Leu Null +85 G>T Val29Leu Null *4 (1076T>C) Ile359Tyr Decreased +121 G>T Ala41Ser Null *5 (1080C>G) Asp360Glu Decreased +134 T>C Val45Ala Null *6 (818delA) Frameshift Null +172 A>G Arg58Gly Null       +1331 G>A Val66Met Null       +3487 T>G Leu28Arg Null Wild-types are assigned as a result of the absence of other SNPs.

Table 2: CYP2C9 and VKORC1 variants detected with HILOMet Warfarin system on Luminex® 100x Map™ technology. Effects on enzymatic activity are also depicted