| Parameter |
Value |
Genotype |
| Ka (hr-1) |
1.17 |
|
| Vd (liters) |
8.0 |
| R0 (INR units) |
2.5 |
| Rin (INR units) |
1.5 |
| IC50 (mg/L) |
1.5 |
| ke (hr-1) |
0.0189 |
*1/*1 |
| 0.0158 |
*1/*2 |
| 0.0132 |
*1/*n |
| 0.0130 |
*2/*2 |
| 0.009 |
*2/n |
| 0.0075 |
n/n |
| Where n= *3, *5 or *6 |
Ka= Absorption rate constant, Vd= Volume of distribution, R0= Rate of elimination,
Rin= Input rate, IC50= half maximal inhibitory concentration, ke= Elimination rate
constant. (These parameters were taken from the literature [34], except ke that
varies according to individual genotype). |
