Prediction Model IWPC algorithm Puerto Rican Algorithm High-Doses (>7 mg/day) MAE (mg/day) 95% CI 4.68 (5.57-3.78) 1.83 (2.64-1.03) R2 (%) 2.34 18.01 p-value 0.0525 Intermediate-Doses (≥ 3 and ≤ 7 mg/day) MAE (mg/day) 95% CI 1.18 (1.33-1.03) 0.52 (0.61-0.42) R2 (%) 0.58 66.74 p-value 1.67x10-10 Low-Doses (<3 mg/day) MAE (mg/day) 95% CI 1.92 (2.28-1.57) 0.53 (0.74-0.33) R2 (%) 1.75 50.24 p-value 0.0259

Table 6: Predicted warfarin daily doses (mg/day) with Puerto Rican population, using our derived pharmacogenetic algorithm and IWPC algorithms as compared to the actual doses of warfarin for the therapeutic effect in patients requiring High- Doses (>7 mg/day), Intermediate-Doses (≥ 3 and ≤ 7 mg/day) or Low-Doses (<3 mg/day) in our study cohort of 131 patients at VACHS anticoagulation clinic.