Model No. of Patients Ideal Dose (%) Underestimate (%) Overestimate (%) High-Doses (>7 mg/day) IWPC algorithm   11 0 100.00 0 Puerto Rican Algorithm 45.45 54.55 0 Intermediate- Doses (≥3 and ≤7 mg/day) IWPC algorithm   97 33.00 43.33 22.68 Puerto Rican Algorithm 79.38 12.37 8.25 Low-Doses (<3 mg/day) IWPC algorithm   23 13.04 4.35 82.61 Puerto Rican Algorithm 52.17 0 47.83 a The ideal dose was defined as a predicted dose that was within 20% of the actual stable therapeutic dose of warfarin, underestimation was defined as a predicted dose that was at least 20% lower than the actual dose, and overestimation was defined as a predicted dose that was at least 20% higher than the actual dose.

Table 7: Percentage (%) of patients in the study cohort with an ideal, underestimated, or overestimated dose of warfarin, as estimated with the IWPC pharmacogenetic algorithm and our pharmacogenetic algorithm (equation 2) in patients requiring low, intermediate, or high doses of warfarin for a therapeutic effecta.