|   | 
          | 
         Percent    of variance explained by matching1 | 
          | 
          | 
        Percent of variance explained by matching1 | 
       
      
        | CXCR2 agonists | 
        CXCL1 | 
        5.6 | 
        Oscillometry | 
        AX  | 
        35.2 | 
       
      
        |   | 
        CXCL3 | 
        0.0 | 
          | 
        R5  | 
        22.0 | 
       
      
        |   | 
        CXCL5 | 
        32.5 | 
          | 
        R15  | 
        5.1 | 
       
      
        |   | 
        CXCL7 | 
        8.1 | 
          | 
        R25  | 
        12.6 | 
       
      
        |   | 
        CXCL8 | 
        0.0 | 
          | 
        RF  | 
        28.2 | 
       
      
        | Inflammatory biomarkers | 
        CC-16 | 
        25.7 | 
          | 
        X5  | 
        34.3 | 
       
      
        |   | 
        Fibrinogen | 
        0.0 | 
        Spirometry | 
        FEV1  | 
        67.9 | 
       
      
        |   | 
        IL-1B | 
        0.0 | 
          | 
        FVC  | 
        57.9 | 
       
      
        |   | 
        MMP9 | 
        4.0 | 
          | 
          | 
          | 
       
      
        |   | 
        SP-D | 
        0.0 | 
          | 
          | 
          | 
       
     
    1Calculated as σb2/(σb2+  σw2) where σb2and σw2are respectively the between- and within-matched-pair variance  components from the ANOVA  |