Relatively severe malformations Cardiovascular Defects Group Total number With drug OR 95% CI With drug OR 95% CI All included 45642 1544 1.09 1.03-1.15 533 1.13 1.04-1.23 Excluding ”teratogens” 42437 1441 1.10 1.04-1.16 491 1.12 1.03-1.23 Excluding all concomitant drugs 23556 794 1.08 1.00-1.16 270 1.11 0.98-1.25 Excluded ”teratogens” are drugs used for functional gastrointestinal disease, drugs used for immunological bowel disease, antihypertensives, systemic glucocorticosteroids, thyroid hormones, and NSAIDs.

Table 3: Effect on relatively severe malformations or cardiovacular defects analyzed with respect to concomitant drug use. Odds ratio (OR) with 95% confidence interval (95% CI). Bold text marks statistical significance.