(Quantification of mtDNA was performed by QPCR on DNA isolated from plasma at baseline (Before) and exit (After) from the study. MtDNA-74 levels in the placebo group increased marginally over time (p=0.7, ratio t test). In contrast, mtDNA-74 levels in the Lo and Hi treatment groups trended downward, but did not reach significance (p=0.1, ratio t test).)
