Intervention 5 HFT Centers
x/n (%) (LCL, UCL)a
VON Data base
(%)
Use of surfactant 805/1363 (59.1) (56.4, 61.7) 62.4
nCPAP 413/1363 (30.3) (27.9, 32.8) 68.6
HFNC 999/1363 (73.3) (70.9, 75.6) 53.0b
CMV 798/1363 (58.5) (55.9, 61.2) 64.6
CMV: Conventional mechanical ventilation; HFNC: High flow nasal cannula; HFT:
High flow therapy; LCL: Lower confidence limit; n: population; nCPAP: nasal
continuous positive airway pressure; UCL: Upper confidence limit; VON: Vermont
Oxford Network; x: number of patients.
aExact 95% binomial confidence limits.
bNote that high flow nasal cannula therapy is the VON definition (cannula flow rate
above 1 L/min), so much of the HFNC use in the VON group is not how we define
HFT (flow rates between 3 L/min and 8 L/min, commonly in the 4 L/min to 6 L/min
range).
Table 3: Comparison of interventions in the 5 HFT study centers and the VON database from 2009-2011.