|   | 
  LC+normal(n=70) | 
  LC+emphysema(n=26) | 
  LC+fibrosis(n=10) | 
  LC+CPFE(n=17) | 
    
   
  | Age, years old | 
  72.5±1.5 | 
  78.8±2.0 | 
  73.8±2.1 | 
  73.9±1.9 | 
    
   
  | Gender, female/male | 
  31/39 | 
  3/23* | 
  1/9 | 
  1/16* | 
    
   
  | Route of diagnosis, n(%) | 
    
   
  | Screening, incidental | 
  46 (65.7%) | 
  15 (57.7%) | 
  4 (40.0%) | 
  10 (58.8%) | 
    
   
  | Symptoms | 
  24 (34.3%) | 
  11 (42.3%) | 
  6 (60.0%) | 
  7 (41.2%) | 
    
   
  | Histology of lung cancer, n(%) | 
    
   
  | Small cell carcinoma | 
  5 (7.1%) | 
  3 (11.5%) | 
  2 (20.0%) | 
  1 (5.9%) | 
    
   
  | Squamous cell carcinoma | 
  11 (15.7%) | 
  10 (38.5%) | 
  4 (40.0%) | 
  10 (58.8%) ** | 
    
   
  | Adenocarcinoma | 
  50 (71.4%) | 
  11 (42.3%) | 
  4 (40.0%) | 
  5 (29.4%) * | 
    
   
  | Large cell carcinoma | 
  3 (4.3%) | 
  2 (7.7%) | 
  0 (0.0%) | 
  0 (0.0%) | 
    
   
  | Other non-small cell carcinoma | 
  1 (1.4%) | 
  0 (0.0%) | 
  0 (0.0%) | 
  1 (5.9%) | 
    
   
  | Clinical stage of non-small cell lung cancer, n(%) | 
    
   
  | StageⅠA,B | 
  31 (47.7%) | 
  5 (21.7%) | 
  1 (12.5%) | 
  6 (37.5%) | 
    
   
  | StageⅡA,B | 
  5 (7.7%) | 
  5 (21.7%) | 
  1 (12.5%) | 
  5 (31.3%) | 
    
   
  | StageⅢA,B | 
  7 (10.8%) | 
  3 (13.0%) | 
  1 (12.5%) | 
  3 (18.8%) | 
    
   
  | StageⅣ  | 
  22 (33.8%) | 
  10 (43.5%) | 
  5 (62.5%) | 
  2 (12.5%) | 
    
   
  | Advanced stage(ⅢB,Ⅳ) | 
  27 (41.5%) | 
  11 (47.8%) | 
  5 (62.5%) | 
  5 (31.3%) | 
    
   
  | Clinical stage of small cell lung cancer, n(%) | 
    
   
  | Limited disease | 
  3 (60.0%) | 
  2 (66.7%) | 
  1 (50.0%) | 
  1 (100.0%) | 
    
   
  | Extended disease | 
  2 (40.0%) | 
  1 (33.3%) | 
  1 (50.0%) | 
  0 (0.0%) | 
    
   
  | Initial treatment for lung cancer, n(%) | 
    
   
  | Surgery | 
  40 (57.1%) | 
  8 (30.8%) | 
  3 (30.0%) | 
  8 (47.1%) | 
    
   
  | Chemotherapy | 
  15 (21.4%) | 
  7 (26.9%) | 
  2 (20.0%) | 
  7 (41.2%) | 
    
   
  | Radiation | 
  4 (5.7%) | 
  1 (3.8%) | 
  0 (0.0%) | 
  0 (0.0%) | 
    
   
  | Best supportive care | 
  14 (20.0%) | 
  10 (38.5%) | 
  5 (50.0%) | 
  2 (11.8%) | 
    
   
  | Primary site of lung cancer, n(%) | 
    
   
  | Right upper lobe | 
  21 (30.0%) | 
  5 (19.2%) | 
  3 (30.0%) | 
  3 (17.6%) | 
    
   
  | Right middle lobe | 
  3 (4.3%) | 
  1 (3.8%) | 
  2 (20.0%) | 
  0 (0.0%) | 
    
   
  | Right lower lobe | 
  25 (35.7%) | 
  12 (46.2%) | 
  0 (0.0%) | 
  6 (35.3%) | 
    
   
  | Right hilum | 
  1 (1.4%) | 
  2 (7.7%) | 
  0 (0.0%) | 
  0 (0.0%) | 
    
   
  | Left upper lobe | 
  9 (12.9%) | 
  3 (11.5%) | 
  3 (30.0%) | 
  4 (23.5%) | 
    
   
  | Left lower lobe | 
  10 (14.3%) | 
  3 (11.5%) | 
  2 (20.0%) | 
  4 (23.5%) | 
    
   
  | Left hilum | 
  1 (1.4%) | 
  0 (0.0%) | 
  0 (0.0%) | 
  0 (0.0%) | 
    
   
  | Location of primary mass, n(%) | 
    
   
  | Upper lobe | 
  30 | 
  8 | 
  6 | 
  7 | 
    
   
  | Non-subpleural | 
  21 (70.0%) | 
  4 (50.0%) | 
  2 (33.3%) | 
  5 (71.4%)† | 
    
   
  | Subpleural | 
  9 (30.0%) | 
  3 (37.5%) | 
  3 (50.0%) | 
  2 (28.8%)‡ | 
    
   
  | Not-differentiated | 
  0 (0.0%) | 
  1 (12.5%) | 
  1 (16.7%) | 
  0 (0.0%) | 
    
   
  | Other sites | 
  40 | 
  18 | 
  4 | 
  10 | 
    
   
  | Non-subpleural | 
  20 (50.0%) | 
  7 (38.9%) | 
  2 (50.0%) | 
  2 (20.0%) | 
    
   
  | Subpleural | 
  16 (40.0%) | 
  10 (55.6%) | 
  2 (50.0%) | 
  8 (80.0%) | 
    
   
  | Not-differentiated | 
  4 (10.0%) | 
  1 (5.6%) | 
  0 (0.0%) | 
  0 (0.0%) | 
    
   
  | Non-emphysematous area | 
  N/A | 
  2 (7.7%) | 
  N/A | 
  4 (23.5%) | 
    
   
  | Emphysematous area | 
  N/A | 
  24 (92.3%) | 
  N/A | 
  13 (76.5%) | 
    
   
  | Non-fibrotic area | 
  N/A | 
  N/A | 
  3 (30.0%) | 
  4 (23.5%) | 
    
   
  | Fibrotic area | 
  N/A | 
  N/A | 
  7 (70.0%) | 
  13 (76.5%) | 
    
   
  | In-fibrotic area | 
  N/A | 
  N/A | 
  0 (0.0%) | 
  4 (30.8%) | 
    
   
  | Fibrotic junction area | 
  N/A | 
  N/A | 
  7 (100.0%) | 
  9 (69.2%) | 
    
   |