| |
Peak VO2, mL/kg/min |
Mean pulmonary artery pressure, mmHg |
Pulmonary vascular resistance index, Wood units•m2 |
Cardiac index, L/min/m2 |
| Percentage Change From Baseline |
n |
0% |
10% |
20% |
n |
0% |
10% |
20% |
n |
0% |
10% |
20% |
n |
0% |
10% |
20% |
| Placebo |
29 |
55.2 |
72.4 |
89.7 |
56 |
50.0 |
67.9 |
76.8 |
50 |
48.0 |
60.0 |
62.0 |
52 |
61.5 |
67.3 |
78.8 |
| All Sildenafil Doses Combined |
77 |
24.7 |
37.7 |
76.6 |
165 |
67.3 |
77.6 |
87.3 |
152 |
64.5 |
72.4 |
75.0 |
154 |
47.4 |
57.1 |
63.6 |
| Low Dose |
24 |
37.5 |
50.0 |
79.2 |
39 |
48.7 |
69.2 |
82.1 |
36 |
52.8 |
66.7 |
66.7 |
37 |
48.6 |
56.8 |
67.6 |
| Medium Dose |
26 |
19.2 |
34.6 |
73.1 |
55 |
74.5 |
80.0 |
85.5 |
49 |
65.3 |
75.5 |
77.6 |
49 |
51.0 |
59.2 |
63.3 |
| High Dose |
27 |
18.5 |
29.6 |
77.8 |
71 |
71.8 |
80.3 |
91.5 |
67 |
70.1 |
73.1 |
77.6 |
68 |
44.1 |
55.9 |
61.8 |
VO2=oxygen consumption.
Numbers represent the percentage of patients having less than or equal to the specified percentage change from baseline for each parameter. |
