|
One step system (in line) (Cellex®) |
Two stepsystem (off line) |
Main principle |
Integrated system: sequences of cell separation-UVA irradiation-infusion |
Mononuclear cell apheresis and separated UVA irradiation of the total harvested cells |
UVA dose |
1.2 J/cm2 |
2 J/cm2 |
Sample collection for quality control |
No |
Yes |
Nb of Vascular access |
One |
Two |
Total duration of course |
1 h 30 min to 2 hours |
3 to 4 hours |
Pediatric use |
Yes but restricted to >40 kg |
Yes-no restriction |
Other limitations |
Cost |
Cell therapy unit required for UVA irradiation |