Drug Brand (Manufacturer) Recommended Dose Dosing Frequency Route Interferon beta- I a Avonex (Biogen Idec) 30 mcg Once weekly IM Interferon beta- Ia Rebif (Pfizer) 22 or 44 mcg Three times weekly SQ Interferon beta- I b Betaseron (Bayer) 0.25 mg Every other day SQ Interferon beta- I b Extavia (Novartis) 0.25 mg Every other day SQ Glatiramer acetate Copaxone (Teva) 20 mg Once daily SQ Mitoxantrone Novantrone (EMD Serono) 5 to 12 mg/m2 Short infusion (about 5 to 15 minutes) every 3 months IV Natalizumab Tysabri (Biogen Idec) 300 mg 1- hour infusion every 4 weeks IV Fingolimod Gilenya (Novartis) 0.5 mg Once daily PO IM: Intramuscular; IV: Intravenous; PO: Per as (by mouth); SQ: Subcutaneous

Table 1: FDA-approved drug therapies for Multiple sclerosis [61].