Gene Fold change cardiomyocytes alone ** Fold change cardiomyocytes +MSC** Fold change cardiomyocytes HO-1+MSC**
B cell lymphoma 2 BCL2 4642 3759 15,592
Bcl-2-like protein 1 BCL2L1 12 9 39
Chemokine (C-C motif) ligand 2 CCL2 6 0.4 94
Chemokine (C-C motif) ligand 5 CCL5 391,549 1,334,310 3,097,523
Hematopoietic progenitor cell antigen CD34 CD34 3.9 0.2 18
CD68 molecule CD68 7 0.4 31
Collagen, type IV, alpha 5 COL4A5 7 0.02 5
Colony stimulating factor 1 CSF1 1 0.1 5
Endothelin converting enzyme 1 ECE1 545 550 906
Endothelin 1 EDN1 529 640 2030
Fas (TNF receptor superfamily member 6) FAS 8 0.5 63
Fibronectin 1 FN1 1 0.1 9
Heme oxygenase 1 HMOX1 8 13 145
Mothers against DPP homolog 8 SMAD7 9 8 16
Transforming growth factor, beta 1 TGFB1 1 0.6 4
Vascular endothelial growth factor A VEGF 7 0.02 14
**Gene expression changes are shown relative to pre-transplant levels in cardiovascular progenitors *** Fold changes are all significant at p<0.05 except CSF-1, FN1, TGFβ1 and VEGF in the cardiomyocyte alone group
Table 1: Gene Expression Changes at day 30 after Transplantation of hESCderived Cardiomyocytes, MSC + Cardiomyocytes or HO-1 MSC +Cardiomyocytes Post Infarction.