 (A) NANOG gene structure is
shown at the bottom. DNAseI HS peaks in H1 ESCs, human cardiomyocytes
(HCM), CD14 monocytes and human pancreatic adenocarcinoma cells
(HPAF) showing the active cis-regulation mark at the upstream P2 promoter
persists in adult differentiated cells, whereas the HS mark observed in the
ESCs at the proximal P1 promoter is extinguished in the adult cells.
(B) A
similar persistence of the HS peak at P2 is observed in mouse adult cells
while the downstream P1 peak is extinguished. |
