Figure 4: Schematic representation comparing mice receiving only 17ß-estradiol (represented by mouse with ‘E’ on abdomen) to those receiving testosterone (represented by mouse with ‘T’ on abdomen) after surgical gonadectomy. Three scenarios (panels a-c) exist regarding testosterone’s conversion and lead to three possible wheel running responses if the estrogens are the primary effecters of activity (panels d-f) and three possible responses if an androgenic effect is also present (panels g-i). T=Testosterone, E=17ß-estradiol, dotted outline=observed outcome from present dataset.