Day 0 Day 30 Day 30 Day 60 Day 60 Day 90 Day 90
Preparation name     at 25°C at  4°C at 25°C at  4°C at 25°C at  4°C
Progesterone HRT Mean API (% of Labeled Amount) 99.51 101.49 101.29 100.04 98.13 73.72 71.24
Cream Number of repetitions 4 4 4 4 4 4 4
 (10% w/w) Standard Deviation 2.13 1.67 2.19 3.86 7.7 4.21 5.9
  Coefficient of Variation (% of Mean) 2.14 1.65 2.6 3.86 7.84 5.71 7.68
Progesterone PLO  Mean API (% of Labeled Amount) 98.67 98.78 100.91 100.13 101.71 69.66 71.24
Transdermal Cream Number of repetitions 4 4 4 4 4 4 4
(10% w/w) Standard Deviation 1.13 1.9 1.14 1.39 2.25 1.26 1.03
  Coefficient of Variation (% of Mean) 1.14 1.9 1.13 1.39 2.21 2.29 1.45
Table 1: Stability data of progesterone (10%) at 25°C and 4°C over a 90 day period in each base (PLO Transdermal Cream and HRT Cream).