Hormones Main effect Consequence Therapeutical implication for NP
Prostaglandins:
PGE2
PGI2
→ antagonizes ADH
→ antagonizes RAAS
Diuresis NSAIDs
Melatonin stimulates ADH
stimulates RAAS
Antidiuresis Melatonin
Sex hormones:
estrogens
progesterone
testosterone
→ stimulates ADH, Renin, Ang II, ANP; inhibits Aldosteron
→ stimulates Aldosteron; antagonizes ADH, ANP
→ stimulates ADH, Renin, Ang II
Antidiuresis Replacement therapy if necessary
PGE2: Prostaglandin E2; PGI2: Prostaglandin I2; ADH: Antidiuretic Hormone; RAAS: Renin-Angiotensin-Aldosterone System; ANP: Atrial Natriuretic Peptide; NSAIDs: Non-Steroidal Anti-Inflammatory Drugs
Table 2: Influence of prostaglandins, melatonin and sex hormones on the antidiuretic and diuretic hormones