Serum insulin concentrations in OGTT and insulin resistance indices Statistical differences IA IB IIA IIB IIC p(IA/IIA) p(IA/IIB) p(IIA/IIB) n=16 n=2 n=20 n=15 n=3 Fasting insulin [μU/ml] 12.1 ± 8.51 7.80 ± 0.00 5.88 ± 3.41 12.11  ± 21.71 12.37  ± 4.37 p<0.03* p>0.05 p>0.05 Fasting insulin > 15 μU/ml 6/16 (37.5%) 0/2 (0%) 1/20 (5%) 1/15 (6,7%) 1/3 (33.3%) p<0.016 p<0.049 p>0.05 Insulin in 2nd hour of OGTT [μU/ml] 69.13 ± 112.74 25.30 ± 0.00 37.71 ± 38.87 31.26  ± 24.44 60.57  ± 29.70 p>0.05 p>0.05 p>0.05 Insulin in 2nd hour of OGTT >75 μU/ml 3/16 (18.8%) 0/2 (0%) 2/20 (9.5%) 1/15 (6.7%) 1/3 (33%) p>0.05 p>0.05 p>0.05 Max insulin in OGTT > 150 μU/ml 5/16 (31.3%) 0/2 (0%) 2/20 (9.5%) 0/15 (0%) 0/3 (0%) p<0.003 p<0.001 p>0.05 HOMA-IR (>3,16) 6/16 (37.5%) 0/2 (0%) 0/20 (0%) 1/15 (6.7%) 1/3 (33.3%) p<0.012 p>0.05 p>0.05 Quickie (<0,34) 11/16 (68.8%) 2/2 (100%) 11/20 (55%) 8/15 (53.3%) 3/3 (100%) p>0.05 p>0.05 p>0.05 Matsuda and de Fronzo (<5) 6/16 (37.5%) 0/2 (0%) 2/20 (10%) 2/15 (13.3%) 1/3 (33.3%) p>0.05 p>0.05 p>0.05

Table 2: Serum insulin concentrations in OGTT and insulin resistance indices in particular groups. IA- group of patients treated surgically for tumors of hypothalamic-pituitary area; IB - group of patients treated with surgery and radiotherapy for tumors of hypothalamic-pituitary area; IIA –group of patients treated with surgery, chemo- and radiotherapy for tumors outside the h-p area; IIB – group of patients treated surgically for tumors outside the h-p area; IIC- patients with optic nerve glioma treated with chemotherapy. Analysis was made by Fisher test. Values marked by “*” were calculated by U Mann-Whitney test. Statistically important differences were marked as bold.