Author

Sample

Treatment

Exercise intervention

Primary end point

Birkeland et al.

20

5000 IU three
times weekly

Cycle ergometry

Hct levels increased 19.0%
(42.7 to 50.8%;P<0.001)
and VO2max
increased 7.5% (P=0.001)

Wilkerson et al.

15

150 IU/kg per week

Cycle ergometry

Hb levels increased 7%
(15.8 – 16.8 g/dl;P < 0.01)
12% in Hct (43- 49%; P < 0.01)
7% improvement in VO2max (P < 0.05)
TTE was extended by 22%
(P < 0.01)

Thomsen et al.

8

5000 IU injections
(per protocol)

Cycle ergometry

Hb increase by an average
of 10.3 % (14.6-15.9 g/dl; P < 0.05)
VO2max by 8.6% (P < 0.05).
TTE was significantly
increased by roughly
54.0% (P < 0.05)

RhEPO: Recombinant human erythropoietin
Hct: Hematocrit
Hb: Hemoglobin
IU: International Units
TTE: Time to exhaustion
Kg: Kilograms
Table 1: Trials with RhEPO versus placebo controlled studies [17-19].