Components

AF

      NP
Water 60-70 %, no change with age 90 % at birth
80 % at age 20
70 % at older age
Collagens (collagen I, collagen II, collagen X-  collagen X is produced by the degenerated disc which has very poor mechanical properties) Only collagen II, 50-60 % with (dry weight) Only collagen I, 15-20 % with (dry weight)
Little change with age Little change with age
PGs (Proteoglycans) 15-20 % with (dry weight) 65% with (dry weight)
Little change with age Little change with age
Non- collagenous proteins and elastin 5-25% with (dry weight) 20-45% with (dry weight)
Little change with age Little change with age
Extracellular enzymes, age pigments, cells Minor remainder Minor remainder
Table 1: Basic components of the IVD [46].