|
Gene name |
H4IIE |
H4H1 |
2D-hepatocyte sandwich |
3D-liver microtissue |
| Day 4 Day 25 |
Day 4 Day 25 |
|
Glucocorticoid pathway |
| PCK1 |
32.0 ± 0.8 |
21.4 ± 1.2 |
33.5 ± 1.3 |
34.3 ± 1.7 |
25.5 ± 0.4 |
27.5 ± 0.1 |
| ORM1 |
30.1 ± 0.4 |
30.0 ± 0.2 |
20.5 ± 2.3 |
25.4 ± 0.3 |
19.6 ± 1.3 |
21.7 ± 1.0 |
| G6PC |
32.3 ± 1.9 |
21.5 ± 0.5 |
34.2 ± 0.6 |
34.1 ± 0.7 |
27.1 ± 0.6 |
27.4 ± 0.1 |
| H6PD |
29.5 ± 1.1 |
30.5 ± 0.5 |
34.1 ± 3.3 |
35.9 ± 0.3 |
30.5 ± 0.6 |
30.8 ± 0.5 |
| H11B1 |
34.7 ± 0.1 |
27.3 ± 0.6 |
31.1 ± 0.4 |
33.7 ± 4.9 |
24.2 ± 0.9 |
23.4 ± 0.4 |
| Anti-oxidant cell defense pathway |
| ABCC3 |
27.0 ± 0.6 |
27.7 ± 0.3 |
28.8 ± 1.3 |
31.6 ± 1.9 |
27.8 ± 1.6 |
28.7 ± 1.2 |
| NQO1 |
24.8 ± 0.4 |
22.9 ± 0.6 |
28.6 ± 0.2 |
30.7 ± 2.1 |
25.6 ± 2.5 |
27.0 ± 1.0 |
| GSTA2 |
24.8 ± 1.7 |
28.8 ± 0.6 |
30.9 ± 1.6 |
33.0 ± 0.7 |
20.5 ± 0.9 |
21.0 ± 1.2 |
| NFE2L2 |
21.3 ± 0.5 |
20.5 ± 0.9 |
28.3 ± 2.2 |
30.6 ± 2.0 |
25.1 ± 1.9 |
24.9 ± 0.1 |
|
Other (redox pathway) |
| G6PD |
23.9 ± 0.8 |
24.7 ± 0.2 |
28.4 ± 0.2 |
30.9 ± 1.9 |
28.4 ± 1.2 |
29.0 ± 1.7 |
|
House-keeping |
| PPIA |
24.1 ± 0.2 |
19.2 ± 0.1 |
22.8 ± 0.5 |
23.5 ± 0.8 |
22.3 ± 0.1 |
21.8 ± 0.7 |
|
