Figure 7: Macroscopic appearance and histological analysis of normal and pathological skin substitutes. Macroscopic and histological analyses of normal and pathological skin substitutes after 21 days of culture at the air– liquid interface (scale bars = 2.2 cm and 50 μm, respectively). Reproduced and modified from Jean et al., 2009 according to the copyright policy of the publisher. 2009 Elsevier.