| IMMUNOSUPPRESSIVE AGENT |
MECHANISM OF ACTION |
| CALCINEURIN INHIBITORS |
Inhibit signal 2 trasduction via T cell receptor |
| MAMMALIAN TARGET OF RAPAMYCIN INHIBITORS |
Inhibit signal 3 trasduction via IL-2 receptor |
| MYCOPHENOLIC ACID |
Inhibits purine and DNA synthesis |
| CORTICOSTEROIDS |
Inhibit cytokine transcription by antigen presenting cell; Selective lysis of immature cortical thymocytes |
| AntiCD3 monoclonal antibodies |
Depletion and receptor modulation in T cell Interferes with signal 1 |
| Antithymocyte globuline |
Depletion and receptor modulation in T cells Interferes with signal 1, 2, 3 Inhibits lymphocytes trafficking |
| Anti IL-2 alpha chain receptor antibodies |
Inhibit T cell proliferation to IL-2 |
| Anti –CD52 monoclonal antibodies |
Cause depletion of thymocytes, T cells, B cells and monocytes |
