Figure 2: Cytotoxicity of infiltrating cells (whole cells) into the transplanted hearts and splenocytes from vehicle- or FR276457-treated allograft recipients. The infiltrating cells (whole cells) into the transplanted hearts of the vehicle-treated allograft recipients showed cytotoxicity against splenocytes as target cells derived from ACI rat (A). The cytotoxicity of whole cells into the transplanted hearts of FR276457-treated allograft recipients was suppressed (A) (N=3 in each group, respectively). Splenocytes as effector cells from vehicle- or FR276457-treated allograft recipient showed little cytotoxicity against target cells from ACI rat (B) (N=1 in each group, respectively). The studies were carried out at different Effector/Target ratios (E:T ratio; 10 to 1 and 30 to 1) to confirm the activity of effector cells.