| Xenotransplantation: Strategy and |
Modification of the pigs |
Recipients (number of animals) |
Results after Tx |
References |
| treatment |
| Cells and heart |
None |
15 baboons |
No PERV transmission and no microchimerism1 year after treatment, 12-24 months |
[117] |
| PAEC (1x107) iv |
| one animal also pig heart, Cyp |
| Heart, skin, encapsulated islets, some CsA, MMF, Ster |
None |
23 (6 baboons, 6 bonnet macaques, 9 STZ rhesus, 2 STZ capuchins |
No PERV transmission, 11-31 months |
[118] |
| Kidney, Cyp, CsA, MMF, Ster |
hCD59 |
6 cynomolgus monkey |
No PERV transmission, 1-19 days |
[119] |
| Kidney |
|
12 cynomolgus monkey |
No PERV transmission, transplant removed days 2-15, up to day 287 |
[120] |
| Encapsulated isleT-cells, no immunosuppression |
None |
12 STZ cynomolgus monkey |
No transmission of PERV and other viruses, 3-8months |
[80] |
| Kidney (13) or heart (14) GAS914, Cyp, CsA, MPA |
hDAF |
27 baboons |
No PERV transmission, 6-50 days |
[121] |
| Liver perfusion 13-24 hours without immunosuppression |
hDAF |
6 baboons |
No PERV transmission, 6-12 months |
[122] |
| Pig neonatal isleT-cell clusters with immunosuppression |
GalTKO+CD55+CD59+H-transferase |
3 baboons |
Reduced xenoantibody response to isleT-cells from transgenic animals |
[49] |
| Pig neonatal isleT-cell clusters with immunosuppression |
GalTKO+CD55+CD59+H-transferase |
5 non-diabetic baboons |
No coagulation incompatibilities, no thrombosis |
[51] |
| Abbreviations: C1inh, complement C1 inhibitor; CsA, Cyclosporine A; CyP, cyclophosphamide; EC, endothelial cells; FTBI, fractionated total body irradiation; GAS914, a soluble, polymeric form of a Galalpha-(1,3)Gal trisaccharide, hDAF, human decay-accelerating factor; MPA, mycophenolic acid; PAEC, primary aortic endothelial cells; Ster, steroids; STZ, streptocotozin (induced diabetes), Tx, transplantation. |
