Factor Relative hazards 95% confidence interval p-value
Acute GVHD II–IV
RIC vs. MAC 0.23 0.10–0.51 < 0.001
Year of HSCT 1.27 1.07–1.52 0.01
Mixed chimerism 0.9 0.40–2.00 0.8
Relapse
RIC vs. MAC 1.62 0.61–4.31 0.34
CsA + MTX 0.35 0.15–0.81 0.014
ATG 4.48 1.36–14.8 0.014
Acute GVHD I–IV 0.45 0.21–0.99 < 0.05
Mortality
RIC vs. MAC 1.39 0.69–2.81 0.36
Adverse cytogenetics 2.31 1.14–4.68 0.02
ATG 2.64 1.00–7.06 0.05
Bone marrow 2.33 1.04–2.39 0.04
Transplant failure (opposite of leukemia-free survival)
RIC vs. MAC 1.61 0.85–3.06 0.14
ATG 3.95 1.51–10.3 0.005
Adverse cytogenetics 2.13 1.10–4.12 0.025
Abbreviations: RIC = Reduced Intensity Conditioning; MAC = Myeloablative Conditioning; ATG = Antithymocyte Globulin; CsA = Cyclosporine; MTX = Methotrexate; GVHD = Graft-Versus-Host Disease.
Table 2: Multivariate analysis for acute GVHD of grades II–IV, relapse, mortality,and transplant failure (leukemia-free survival).