Parameter Unit Mean ± SD
Cmax μg/mL 15.89± 0.85
AUC0-24h μg*h/mL 45.90 ± 0.30
MIC(serum) μg/mL 0.75 ±0.00
MBC(serum) μg/mL 0.95 ± 0.05
MPC μg/mL 6.0 ± 0.00
Cmax/ MIC - 21.00± 0.80
AUC0-24h/ MIC h 61.00± 0.30
Cmax/ MBC  - 17.00± 0.80
AUC0-24h/ MBC h 48.00 ± 0.40
Cmax/ MPC - 2.60 ± 0.80
AUC0-24h/ MPC h 7.62 ± 0.30
Cmax: peak concentration; AUC: area under the curve; Cmax/MIC = ratio of in vivo Cmax to in vitro MIC; AUC0-24h/MIC: ratio of in vivo AUC for 24 h to in vitro MIC; Cmax/ MBC: ratio of in vivo Cmax to in vitro MBC; AUC0-24h/MBC: ratio of in vivo AUC for 24 h to in vitro MBC; Cmax/MPC: ratio of in vivo Cmax to in vitro MPC; AUC0-24h/MPC: ratio of in vivo AUC 24 h to in vitro MPC. *PK data was taken from work of Baxla et al. [20].
Table 2: Integration of *PK-PD data obtained from buffalo calves (n=5) administered with gentamicin by intravenous route (5 mg/kg).