IgG2a/IgG1 ratioc

Preimmunized with:

 
Weekb
DENV1

DENV2

DENV3

DENV4

JEV

YFV
DENV2

 

0
64
2
64
1
-d
-
6
2048
16
512
8
-
-

Controla

6
512
16
64
16
-
-

JEVAX

0
1/2
1/4
1/64
1/2
1
-
6
16
2
8
2
1
-
Control
6
512
32
16
16
8
-
YFV
0
4
1/8
1
1/4
-
4
6
64
1
4
4
-
1
Control
6
512
32
16
16
-
8

aInoculated with PBS
bPeriod (week) after the first vaccination with the dengue tetravalent DNA vaccine. 0 indicates the time point just before the first vaccination
cThe ratio of IgG2a to IgG1 antibody titers against each of the viruses: DENV14, JEV and YFV
dNot tested.
Table 2: IgG isotype profi les of the antibodies induced in mice preimmunized with flavivirus antigens and then vaccinated with the dengue tetravalent DNA vaccine.