Figure 4: Survival of mice that were immunized nasally with a low dose of PspA plus each TLR agonist, a low dose of PspA alone and PBS alone after pneumococcal pneumonia. Immunized mice were intranasally challenged with 2 107 cfu of pneumococcal strain WU2, and the survival of the mice was monitored for 16 days. Results were examined by a Kaplan-Meier survival curve analysis for ten mice per group. *p < 0.05, when compared with mice that were nasally immunized PspA alone. **p < 0.01, when compared with mice that were nasally immunized PBS alone. ***p < 0.001, when compared with mice that were nasally immunized PspA alone or PBS alone.