Fed animals

Mean of % inhibition in fed animals ( ±SD )

Results

Cat 1

13.0 ±0.3

Positive

Cat 2 (fed)

16.2 ± 0.7

Positive

Cat 3 (fed)

10.0 ± 0.5

Positive

Cat 4 (non fed)

1.37 ± 0.07

Negative

Cat 5 (non fed)

1.63 ± 0.04

Negative

The results of this experiment suggest that the feline anti-HIV-gp120 antibodies were anti-anti-idiotypic antibodies, able to inhibit the binding of HIV-gp120 peptide to anti-HIV-gp120 antibodies. The results showed statistically significant difference between the means of % inhibition of fed and non-fed animals, p = 0.015.
Table 4: Inhibition of the HIV-gp120 peptide and anti-HIV-gp120 Ab reaction by anti-anti-idiotypic HIV-gp120 antibodies