Group A: HAV vaccine Day 7 & MMR Vaccine Day 28

Group B: MMR vaccine Day7 & Hav vaccine Day 28

Group C: HAV vaccine & MMR vaccine Day 0

Day -7 Day 28

Day 213

Day 243

Day -7 Day 28

Day 213

Day 243

Day -7 Day 28

Day 213

Day 243

N Data†

172

172

154

154

85

84

79

80

164

164

148

148

GMC (mIU/mL)

5.01

46.78

217.11

5078.74

5.06

3.67

97.92

3271.00

5.40

42.42

144.06

4314.86

[95% CI]

[4.54;5.53]

[42.43;51.58]

[191;246]

[4433;5818]

[4.38;5.85]

[3.28;4.11]

[78.58;122.02]

[2657.9;4025.6]

[4.83;6.04]

[38.86;46.30]

[127.0;163.4]

[3757.76;4954.54]

≥5 mIU/mL
% (n)


59.3 (102)


98.3 (169)


100.0 (154)


100.0 (154)


60.0 (51)


39.3 (33)


100.0 (79)


100.0 (80)


61.6 (101)


100.0 (164)


100.0 (148)


100.0 (148)

[95% CI]

[50.87;65.44]

[94.99;99.64]

[97.6;100.0]

[97.63;100.0]

[48.80;70.48]

[28.80;50.55]

[95.44;100.0]

[95.49;100.0]

[53.68;69.06]

[97.78;100.0]

[97.54;100.0]

[97.54;100.0]

≥20 mIU/mL
% (n)


1.2 (2)


93.6 (161)


100.0 (154)


100.0 (154)


1.2 (1)


1.2 (1)


94.9 (75)


100.0 (80)


3.6 (6)


92.7 (152)


99.3 (147)


100.0 (148)

[95% CI]

[0.14;4.14]

[89.2;96.8]

[97.6;100.0]

[97.6;100.0]

[0.03;6.39]

[0.03;6.46]

[87.54;98.60]

[95.49;100.0]

[1.35;7.79]

[87.57;96.1]

[96.3;99.9]

[97.54;100.0]

GMCR

NA

9.34

NA

23.39

NA

NA

NA

33.50

NA

7.85

NA

29.95

[95% CI]

[8.07;10.79]

[20.7;26.4]

[28.36;39.58]

[6.84;9.01]

[26.35;34.05]

NA Not Applicable; GMC - Geometric Mean Concentration; GMCR Geometric Mean Concentration Ratio: geometric mean of individual anti-HAV concentration ratios, Day 28: Day 7 and Day 243: Day 213
Table 1: Anti-hepatitis A GMC, GMCR and seroprotection rates by micro enzyme immunosorbent assay (MEIA) at enrollment, one month after primary vaccination (Day 28), at booster administration (Day 213) and 1 month after booster administration (Day 243).