Gene Nucleotide Protein Amino acid
No. Lwt1 L17-MDV2 VN/H5N1-RG LAIV3 VN/H5N2 LAIV4 t/T/H5N2 LAIV5 No. Lwt L17-MDV VN/H5N1-RG LAIV VN/H5N2 LAIV t/T/H5N2 LAIV
PB2 1459 G T T T T PB2 478 Val Leu Leu Leu Leu
PB1 360 G A A A A PB1 112 Glu Glu Glu Glu Glu
819 G T T T T 265 Lys Asn Asn Asn Asn
1795 G A A A A 591 Val Ile Ile Ile Ile
1011* A A A G A 329* Gln Gln Gln Gln Gln
PA 107 T C C C C PA 28 Leu Pro Pro Pro Pro
222 T C C C C 66 Asp Asp Asp Asp Asp
1045 G T T T T 341 Val Leu Leu Leu Leu
NA 765* G G G T T NA 249 Arg Arg Arg Ile Ile
1116 T C C C C 366 Ile Thr Thr Thr Thr
M 68 A G G G G M1 15 Ile Val Val Val Val
457 T G G G G 144 Phe Leu Leu Leu Leu
NS 798 G A A A A NS2 100 Met Ile Ile Ile Ile
HA 50* - - T C - HA 8 - - Phe Leu -
417* - - T C - 130 - - Ile Thr -
Symbols are used here and in the following Tables and Figures:
1Lwt corresponds to A/Leningrad/134/57 (H2N2) wild-type virus, a precursor of A/Leningrad/134/17/57 (H2N2) MDV;
2L17-MDV corresponds to A/Leningrad/134/17/57 (H2N2) MDV;
3VN/H5N1-RG LAIV corresponds to A/17/Vietnam/1203/04-RG (H5N1) LAIV candidate;
4VN/H5N2 LAIV corresponds to A/17/Vietnam/04/65107 (H5N2) LAIV candidate;
5t/T/H5N2 LAIV corresponds to A/17/turkey/Turkey/05/133 (H5N2) LAIV candidate.
*additional mutations of H5N2 LAIV candidates
Table 2: Nucleotide and amino acid differences between A/Leningrad/134/57(H2N2) wild–type virus, A/Leningrad/134/17/57(H2N2) MDV, and H5-LAIV candidates.