COPD stage Before vaccination After 3 months After 6 months After 12 months unit/ml unit/ml unit/ml unit/ml 1 (n=2) 1.59 ± 0.33 2.72 ± 1.19 0.92 ± 0.32 0.93 ± 0.27 2 (n=21) 0.84 ± 0.07 1.54 ± 0.25*** 1.37 ± 0.16*** 1.29 ± 0.12*** 3 (n=14) 0.89 ± 0.1 1.61 ± 0.31*** 1.39 ± 0.14*** 1.26 ± 0.12*** 4 (n=4) 0.96 ± 0.11 2.79 ± 1.2 2.54 ± 0.59 2.12 ± 0.46 Total (n=41) 0.91 ± 0.06 1.76 ± 0.21*** 1.47 ± 0.12*** 1.35 ± 0.09*** Note: *** - p<0.001 – as compared to baseline values.

Table 2: Changes of post-vaccination levels of IgG antibodies to capsular polysaccharide of H. influenzae type b in patients with COPD