Figure 1: Serum IgG (A) and vaginal IgA (B) responses to TT (1 μg/ dose) in BALB/c mice treated or untreated for 8 days with RA (20 μg/dose/day) or its vehicle (sesame oil), intranasally immunized with TT (1 μg/dose) in the presence or in the absence of CT (0.5 μg/ dose) four times. Results are expressed as the IgG or IgA geometric mean titer (GMT). The anti-TT IgG titer was determined in sera and the anti-TT specific IgA in vaginal washes collected one week after fourth immunization. Bars indicate the SEM and stars (*) indicate that the differences between the group treated with RA and the groups treated with RA-vehicle or untreated mice are significant.