Group APR8 subvirion vaccine Adjuvant Aluminium hydroxide PIM2 PBS - - - 10V 0.2 - - 1V 0.02 - - 1V-Al 0.02 200 - 1V-PIM2 0.02 - 35 1V-Al-PIM2 0.02 200 35

Table 1: Vaccine composition for each vaccination group (μg/50 μl dose).