Group Affected bronchiole (%) Bronchiolar exudate BE-neutrophil infiltration BE-necrosis Total pathological score PBS 60.0,55.5-62.5a 3.0, 3.0-4.0a 4.0, 3.0-4.0a 2.0, 2.0-4.0a 38.6, 31.6-38.6a 10V 10.0, 3.6-38.9b 1.0, 0.0-1.0b 1.0, 1.0-2.0b 1.0, 1.0-1.0bc 11.0, 10.1-28.4b 1V 50.0, 34.6-56.3a 3.0, 2.0-3.0a 3.0, 2.0-3.0ab 2.0, 1.0-4.0ab 27.5, 25.4-35.6a 1V-Al 5.0, 0.00-23.1b 0.0, 0.0-1.0 b 1.0, 0.0-3.0c 0.0, 0.0-1.0cd 18.2, 9.0-20.1b 1V-PIM2 48.0, 7.1-50.0a 3.0, 2.0-3.0a 3.0, 1.0-3.0abc 2.0, 1.0-3.0ab 31.5, 20.1-32.5a 1V-Al-PIM2 4.6, 4.6-10.7b 1.0, 1.0-1.0b 1.0, 1.0-1.0c 0.0, 0.0-0.0d 10.1, 6.1-20.1 b

Table 2: Bronchiole pathological scores (median, interquartile range) of the left lung collected from Trial-2 mice three days post influenza virus challenge (refer to Figure 1 for vaccination history). Medians that do not share a letter are significantly different (p<0.05, Kruskal-Wallis test). BE: Bronchiolar Epithelium.